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5-hydroxytryptamine and rel...
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monografia Rebiun25155472 https://catalogo.rebiun.org/rebiun/record/Rebiun25155472 m o d cr ||||||||||| 841010s1966 gw a o 000 0 eng d 851386315 934994073 936316522 968651896 1012462888 9783642854675 electronic bk.) 3642854672 electronic bk.) 9783540035367 3540035362 9783642854699 3642854699 10.1007/978-3-642-85467-5 doi AU@ 000051665368 NZ1 15004724 NZ1 15327108 UCA Rebiun04067342 KIJ eng pn KIJ UV0 OCLCQ OCLCO AU@ GW5XE OCLCO OCLCQ OCLCF COO OCLCQ EBLCP OCLCQ YDX UAB OCLCQ OCLCO OCLCA LEAUB OCLCQ MMG bicssc MED071000 bisacsh 615 23 5-hydroxytryptamine and related indolealkylamines contributors, H. Blaschko [and others] / sub-editor, Vittorio Erspamer Berlin Springer 1966 Berlin Berlin Springer 1 online resource (xx, 928 pages) illustrations 1 online resource (xx, 928 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier Handbuch der experimentellen Pharmakologie, New series v. 19 1. Histology of the enteroehromaffin cell system -- I. Introduction -- II. The elements of the enterochromaffin cell system -- III. Histochemical characteristics of 5-HT of diagnostic importance -- A. Fixability characteristic -- B. Colour reaction -- 1. Chromaffin reactio -- 2. Argentaffin reactions and argentophil -- 3. Diazo reaction -- 4. Pearse's thyo-indoxyl reaction -- 5. Other reactions -- 6. Reactions which do not give the expected positive response -- 7. Various procedures -- C. Fluorescence as a diagnostic criterion -- D. Limits of histochemical diagnosability of 5-HT -- E. Histochemical data obtained by destructive extra-situm methods -- IV. The enterochromaffin cell syste -- A. Enterochromaffin cells -- 1. The typical enterochromaffin cell -- a) Specific granules --?) Histochemical characteristics --?) Histophysical characteristics --?) Ultrastructural data --?) Data obtained by homogenization and differential centrifugation -- b) Topographical distribution --?) Intestinal distribution --?) Extra-intestinal localization -- c) Taxonomical distribution -- 2. Brief notes on the argentophil pre-enterochromaffin cells -- 3. Embryology of the enterochromaffin cell -- a) Time of appearance of the enterochromaffin cell -- b) Experimental embryological data -- c) Origin of the enterochromaffin cell -- 4. Various functional conditions of the enterochromaffin cell -- B. Chromaffin cells of the posterior salivary glands of Octopoda -- C. Chromaffin cells in the hypobranchial gland of Muricidae -- D. Cutaneous poison glands in Amphibians -- E. Chromaffin cells in Calliactis parasitica -- F. Poison gland cells of some scorpions -- G. Mast cells in the rat and the mouse -- V. Localizations of phenolic and indolic substances which cannot be referred to 5-H -- VI. Localizations of 5-HT which cannot be histochemically demonstrated -- VII. Final considerations -- VIII. Technical appendix -- A. Fixations -- 1. Formalin fixation -- 2. Freezing drying -- 3. Fixation for electron-microscopy -- B. Principal reactions -- 1. Chromaffin reactions -- a) Fixation for chromaffin reaction -- b) Reaction on sections -- 2. Iodaffin reactions -- 3. Silver reactions -- a) Argentaffin reaction according to Masson-Hamperl -- b) Argentaffin reaction according to Masson -- c) Methenamine silver argentaffin reaction according to Gomori-Burtner -- d) Bodian's argyrophil technique -- e) Gross-Schultze's modification of Bielchowski's argyrophil technique -- f) Feyrter's adaptation of Gross-Schultze's argyrophil technique to paraffin embedded sections -- 4. Schmorl's reaction -- 5. Diazoreactions -- a) Diazoreaction with the diazotate of sulfanilic acid --?) In alkaline solution --?) In acid solution --?) In alkaline solution with subsequent strong acidification -- b) Diazoreaction with stabilized diazotates -- c) Coupled tetrazonium reaction according to Pearse -- d) Diazosafranin method according to Lillie, Burtner and Henson -- 6. Gibbs's dichloroquinonechlorimide reaction -- 7. Pearse's thioindoxyl reaction -- C. Estimation of the weighted index of granularity in the rat according to Ghiringhelli and Mira -- References -- 2: Chemical analysis of indolealkylamines and related compounds -- A. Isolation and fractionation from biological materia -- I. Extraction procedures -- 1. Acetone extraction -- 2. Butanol extraction -- 3. Other solvent extractions -- II. Chromatographic procedures -- 1. Adsorption chromatography -- 2. Ion exchange chromatography -- 3. Paper chromatography -- 4. Molecular sieving (gel filtration) -- III. Paper electrophoresis -- B. Identification -- I. Ultraviolet absorbancy -- II. Fluorescence -- III. Colour reactions -- 1. Aldehyde reactions -- 2. Xanthydrol reaction -- 3. l-Nitroso-2-naphthol reaction -- 4. Diazo reactions -- IV. Countercurrent distribution -- V. Paper chromatography -- 1. Chromatography paper -- 2. Solvent systems -- 3. Location of spots -- 4. Rf values of indolealkylamines and related compounds -- 5. Quantitative paper chromatography -- VI. Thin layer chromatography -- VII. Gas chromatography -- VIII. Paper electrophoresis -- C. Quantitative determination of specific compounds -- I. Simple indoles -- 1. Tryptamine -- 2. Tryptophan -- 3. Indoleacetic acid -- II. 5-Hydroxyindoles -- 1. 5-Hydroxytryptamine -- 2. 5-Hydroxytryptophan -- 3. 5-Hydroxyindoleacetic acid -- References -- 3: Bioassay of indolealkylamines -- I. Extraction of 5-HT and related indolealkylamines from tissues and organic fluids -- II. Smooth muscle preparations used in the bioassay of indolealkylamines -- 1. Rat uterus -- a) Erspamer's original method -- b) Gaddum's technique -- 2. Rat fundus strip -- 3. Rat colon -- 4. Guinea-pig ileum -- 5. Isolated rabbit ear -- 6. Molluscan heart -- a) Venus inercenaria -- b) Helix (several species) -- c) Spisula (Mactra) solida -- d) Anodonta cygnea -- e) Other molluscs -- 7. Miscellaneous preparations -- III. The relative potency of natural and synthetic indolealkylamines -- References -- 4: Occurrence of indolealkylamines in nature -- I. Introduction -- II. Vertebrates -- 1. Gastro-intestinal tract -- 2. Blood -- 3. Spleen -- 4. Mast cells -- 5. Other extracerebral tissues of mammals -- 6. Central and peripheral nervous system -- 7. Venom of reptiles -- 8. Amphibian skin -- 9. Fish tissues and venoms -- 10. Urine -- 11. Biological fluids and liquids other than urine -- III. Invertebrates -- IV. Plants -- References -- 5: Biosynthesis of indolealkylamines. Physiological release and transport of 5-hydroxytryptamine -- I. Introduction -- II. The hydroxylation of tryptophan -- III. The decarboxylation of 5-hydroxytryptophan -- 1. The identity of 5-hydroxytryptophan decarboxylase with dopa decarboxylease -- 2. Distribution of 5-hydroxytryptophan decarboxylase (dopa decarboxylase) within the body -- 3. Intracellular distribution of 5-hydroxytryptophan decarboxylase (dopa decarboxylase) -- 4. Pyridoxal phosphate as a coenzyme of 5-hydroxytryptophan decarboxylase (dopa decarboxylase) -- 5. Substrate specificity of 5-hydroxytryptophan decarboxylase (dopa decarboxylase) -- 6. Inhibitors of 5-hydroxytryptophan decarboxylase (dopa decarboxylase) -- 7. Studies on 5-hydroxytryptophan decarboxylase (dopa decarboxylase) in vivo -- 8. Mechanism of the decarboxylase reaction -- 9. Differences in 5-hydroxytryptophan decarboxylase activity with age -- IV. Biosynthesis of melatonin -- V. Storage of 5-hydroxytryptamine -- VI. Turnover of 5-hydroxytryptamine -- References -- 6: Metabolism of indolealkylamines -- A. Introduction -- B. Enzymes acting on indolealkylamines -- I. Amine oxidases -- 1. The intracellular (and carbonyl-reagent-intensitive) amine oxidase -- a) Preparation of amine oxidase -- b) Intracellular localization of amine oxidase -- c) Distribution of amine oxidase -- d) Histochemistry of amine oxidase -- e) Indolealkylamines as substrates of amine oxidase --?) Tryptamine and 5-hydroxytryptamine --?) N-substituded amines --?) Other indolealkylamines -- 2. Amine oxidases inhibited by carbonyl reagents -- 3. Microsomal deaminating enzymes -- 4. Microsomal demethylating enzymes -- II. Reactions of the phenolic hydroxyl groups -- 1. Hydroxyindole oxidases -- 2. Conjugases and dephosphorylase -- 3. Hydroxyindole-O-methyl transferase -- III. Introduction of the phenolic hydroxyl groups -- IV. Introduction of N-methyl groups -- V. N-acetylase -- VI. Oxidative deamination and transamination involving 5-hydroxytryptophan -- 1. Amino-acid oxidases -- 2. Transaminases -- C. Metabolism of indolealkylamines -- I. Metabolites arising from deamination reactions -- 1. Metabolites of tryptamine and of its N-methylated derivatives -- 2. Metabolites of 5-hydroxytryptamine and related amines -- a) 5-Hydroxytryptamine -- b) Other 5-hydroxyindolealkylamines -- c) Derivatives of 5-hydroxyindoles -- 3. 4-Hydroxyindoles -- II. N-Acetylated metabolites -- III. Excretion of O-sulphates -- IV Excretion of O-glucuronides -- V. Formation and excretion of phenolic compounds -- VI. Metabolism of melatonin -- D. Summary -- References -- 7: Peripheral physiological and pharmacological actions of indolealkylamines. By -- I. Acute toxicity of indolealkylamines -- II. Action on the systemic blood pressure -- III. Action on special vascular areas -- 1. Coronary vascular bed -- 2. Pulmonary vessels -- 3. Liver vessels -- 4. Spleen vessels -- 5. Vessels of the placenta -- 6. Musculo-cutaneous vessels -- 7. Vessels of the kidney -- 8. Brain vessels -- 9. Vessels of the retina -- 10. Vasa vasorum -- 11. Other vascular areas -- 12. Effect of local application of 5-HT -- 13. Action of 5-HT on isolated artery strips or rings -- 14. Conclusive remarks -- IV. Action on vascular permeability -- V. Action on capillary resistance -- a) Action of endogenous 5-HT on capillary resistance -- b) Action of exogenous 5-HT on capillary resistance -- c) Therapeutical trial of 5-HT in haemorrhagic syndromes ascribed to increased capillary fragility -- VI. Participation in the mechanism of haemostasis -- VII. Action on the heart -- 1. Heart in situ -- 2. Heart-lung preparation -- 3. Isolated heart -- 4. Isolated atrium -- 5. Papillary muscle -- 6. Strips of turtle and frog ventricle -- 7. Heart of molluscs -- 8. Heart of crustaceans -- VIII. Action on the circulation and the function of the kidney -- IX. Action on cellular permeability -- X. Action on extravascular smooth muscles -- 1. Gastro-intestinal tract -- 2. Extrahepatic biliary tract -- 3. Bronchial smooth muscle -- 4. Uterus -- 5. Urinary bladder -- 6. Ureter -- 7. Seminal vesicles -- 8. Spleen -- 9. Nictitating membrane -- 10. Iris smooth muscle -- 11. Chick amnion -- 12. Molluscan smooth muscle -- 13. Muscles of worms -- 14. Muscles of sea anemones -- XI. Action on respiration -- XII. Action on external secretions -- 1. Salivary secretion -- 2. Gastric secretion -- 3. Pancreatic and biliary secretions -- 4. Sweat secretion -- XIII. Metabolic effects Amines Indole Serotonin Serotonin Indoles Amines. Indole. Serotonin. Electronic books Blaschko, Hermann Erspamer, Vittorio Print version 9783642854699 Handbuch der experimentellen Pharmakologie. New series v. 19