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Analgesia / contributors, F...
Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample, theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain
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monografia Rebiun25202422 https://catalogo.rebiun.org/rebiun/record/Rebiun25202422 m o d cr cn||||||||| 081017s2007 gw a ob 001 0 eng d GBA693328 bnb 94483966 225361578 228376896 608295613 628821413 648128921 698462071 756424462 880112520 988806957 994844965 1001351581 1005772405 1011353502 1019999598 1035660694 1040564609 1044136214 1044612212 1056298017 1056372286 1056497782 1086853867 1089407406 1091727240 1097316054 1097849453 1100938494 1105597259 1110737586 1110920597 1112527084 9783540338239 3540338233 3540338225 Cloth) 9783540338222 Cloth) 6610745250 9786610745258 10.1007/978-3-540-33823-9. doi AU@ 000042134301 AU@ 000048713280 AU@ 000058156585 AU@ 000060544666 DEBSZ 442810334 HEBIS 192072641 NZ1 12054324 NZ1 14776689 978-3-540-33822-2 Springer http://www.springerlink.com GW5XE eng pn GW5XE N$T YDXCP W2U CEF UAB OCLCE E7B OCLCQ IDEBK OCLCQ OCLCO OCLCQ A7U OCLCQ OCLCF BEDGE COO NUI AU@ EBLCP SLY DEBSZ OCLCQ Z5A OTZ OCLCQ YDX VT2 TFH OCLCO OCLCA CASUM MERER STF OCLCQ CRU OCLCQ OCLCO OCLCQ ICG YOU CANPU U3W WYU OCLCO UX1 OCLCQ CNTRU OCLCQ UKAHL AUD ZHM DCT ERF WURST OCLCQ OCLCA OCLCQ OCLCA dlr RM lcco QP lcco MED 093000 bisacsh MMG. bicssc 615.783 22 R971 clc Analgesia contributors, F. Benedetti [and others] ; editor, Christoph Stein Berlin New York Springer 2007 Berlin New York Berlin New York Springer 1 online resource (viii, 435 pages) illustrations 1 online resource (viii, 435 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Handbook of experimental pharmacology 0171-2004 v. 177 Includes bibliographical references and index Part I. Introduction --) Peripheral and central mechanism of pain generation H.G. Schaible -- Part II.) Drugs in clinical use -- Opioids C. Zöllner, C. Stein. -- Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolionones B. Hinz, K. Brune. -- Local anesthetics R. Yanagidate, G.R. Strichartz. -- Serotonin receptor ligands: treatments of acute migraine and cluster headache P.J. Goadsby. -- Anti-convulsants and anti-depressants A.H. Dickenson, J. Ghandehari -- Part III.) Compounds in preclinical development -- Neuropeptide and kinin antagonists R.G. Hill, K.R. Oliver. -- Glutamate receptor ligands V. Neugebauer. -- Adrenergic and cholinergic compounds R.D. Sanders, M. Maze. -- Cannabinoids and pain I.J. Lever, A.S.C. Rice -- Part IV.) Future targets in analgesia research -- Adenosine and ATP receptors J. Sawynok. -- Ion channels in analgesia research J.N. Wood. -- Protein kinases as potential targets for the treatment of pathological pain R.R. Ji, Y. Kawasaki, Z.Y. Zhuang, Y.R. Wen, Y.Q. Zhang -- Part V.) Pain Management beyond pharmacotherapy -- Placebo and endogenous mechanisms of analgesia F. Bededetti. -- Limitations of pharmacotherapy: behavioral approaches to chronic pain H. Flor, M. Diers. -- Subject index Use copy. Restrictions unspecified star. MiAaHDL Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample, theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain Electronic reproduction. [Place of publication not identified] HathiTrust Digital Library 2010. MiAaHDL Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Analgesia Analgesics Pain- Treatment Analgesics- pharmacokinetics Analgesia Pain- drug therapy MEDICAL- Pain Medicine Analgesics Pain- Treatment Analgesics- Pharmacokinetics Analgesia Pain- drug therapy Biomédecine Sciences de la vie Analgesia Analgesics Pain- Treatment Analgetikum anesthesie anaesthesia neurologie neurology chirurgie surgery farmacologie pharmacology toxicologie toxicology psychologie psychology reumatiek rheumatism biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Electronic books Benedetti, F. Fabrizio) Stein, Christoph 1954-) Print version Analgesia. Berlin ; New York : Springer, 2007 3540338225 9783540338222 (OCoLC)75713034 Handbook of experimental pharmacology v. 177. 0171-2004