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Animal models of T cell-med...
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery
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monografia Rebiun25204375 https://catalogo.rebiun.org/rebiun/record/Rebiun25204375 m o d cr |n||||||||| 040428s2004 gw a ob 101 0 eng c 2004106459 276801660 317881339 607298270 647650766 698452690 994756380 1005764783 1035710171 1044234559 1056395411 1073062865 1078871043 1097264201 1102294838 3540210679 9783540210672 9783540268116 3540268111 6610745579 9786610745579 AU@ 000048702885 978-3-540-21067-2 Springer http://www.springerlink.com COO eng pn COO GW5XE CAI DAY IDEBK IAK OCLCQ E7B UBC OCLCQ IAK OCLCO OCLCQ OTZ ESU VT2 IBK OCLCF STF UAB OCLCQ CEF U3W OCLCQ WYU YOU CANPU LEAUB CNTRU UKAHL AUD OCLCQ pcc 573.5/39 22 Animal models of T cell-mediated skin diseases T. Zollner, H. Renz, K. Asadullah, editors 1st ed Berlin New York Springer-Verlag Berlin Heidelberg 2004 Berlin New York Berlin New York Springer-Verlag Berlin Heidelberg 1 online resource (xiii, 291 pages) illustrations (some color) 1 online resource (xiii, 291 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier Ernst Schering Research Foundation workshop 50 Includes bibliographical references and index Making of gene modified mice / M. Pasparakis -- High-throughput gene knockouts and phenotyping in mice / M.W. Moore -- Modelling gene-environment interactions in Th1- and Th2-dominated diseases of laboratory animals / G.A.W. Rook, R. Martinelli, L. Rosa Brunet -- Animal models of experimental asthma / M. Wegmann, H. Renz -- Models for rheumatoid arthritis / R.O. Williams -- Animal models of inflammatory bowel diseases / M.F. Neurath -- Murine models of atopic dermatitis / T. Brzoska, T.A. Luger -- Epicutaneous sensitization with allergens as atopic dermatitis model / H. Alenius -- T cell receptor transgenic models of inflammatory disorders : relevance for atopic dermatitis / U. Niesner, F. Hardung, A. Scheffold -- What must a model display to proof as a model for psoriasis? / W. Sterry, J. Foerster -- From classical mouse models of psoriasis to a spontaneous Xenograft model featuring use of AGR mice / F.O. Nestle, B.J. Nickoloff -- The psoriasis SCID mouse model : a tool for drug discovery? / W.-H. Boehncke -- Pro- and anti-inflammatory effects of IL-4 : from studies in mice to therapy of autoimmune diseases in humans / T. Biedermann, M. Röcken -- What must a model display to proof as a model for contact dermatitis? / C. Hauser -- Acute and chronic models of allergic contact dermatitis : advantages and limitations / T.M. Zollner, F.H. Igney, K. Asadullah -- Transgenic mice expressing IFN-y in the epidermis are a model of inflammatory skin disease and systemic Lupus Erythematosus / F.M. Watt Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery Skin- Inflammation- Animal models- Congresses T cells- Congresses Immunologic diseases- Animal models- Congresses Immunologic diseases- Animal models T cells Electronic books Conference papers and proceedings Zollner, T. Thomas M.) Renz, H. Harald) Asadullah, K. Khusru) () Gutiérrez de Terán, Ignacio Gutiérrez de Terán, Ignacio 1967-) Print version Animal models of T cell-mediated skin diseases. 1st ed. Berlin ; New York : Springer-Verlag Berlin Heidelberg, 2004 3540210679 9783540210672 (DLC) 2004106459 (OCoLC)57676147 Ernst Schering Research Foundation workshop 50