Descripción del título
Advances in Chronic Lymphoc...
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
Monografía
monografia Rebiun36033239 https://catalogo.rebiun.org/rebiun/record/Rebiun36033239 m o d | cr -n--------- 130906s2013 xxu| s |||| 0|eng d 9781461480518 9781461480525 9781461480501 9781493953899 10.1007/978-1-4614-8051-8 doi UMA.RE eng MJCL bicssc MED062000 bisacsh 610 Advances in Chronic Lymphocytic Leukemia Recurso electrónico] edited by Sami Malek New York, NY Springer New York 2013 New York, NY New York, NY Springer New York New York, NY Springer New York Imprint: Springer 2013 New York, NY New York, NY Springer New York Imprint: Springer XI, 334 p. 25 il., 24 il. col XI, 334 p. 25 il., 24 il. col Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology 792 Description based upon print version of record Includes bibliographic references and index Preface -- B-cell receptor and antigens in CLL -- The CLL cell microenvironment -- Acquired genomic copy number aberrations in CLL -- Recurrent gene mutations in CLL -- TP53 aberrations in CLL -- Gene expression and epigenetic deregulation -- Apoptosis deregulation in CLL -- Richter's Syndrome -- Molecular biomarkers in chronic lymphocytic leukemia -- Critical Signal Transduction Pathways in CLL -- Immunotherapies in CLL -- Novel therapeutic agents in CLL -- Inherited susceptibility to CLL -- miR deregulations in CLL -- Index Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia. English Oncology Cancer Research. Oncology Cancer Research Malek, Sami ed. lit 1-4614-8050-7 Advances in Experimental Medicine and Biology 792