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Biocombinatorial approaches...
Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities
Monografía
monografia Rebiun21523162 https://catalogo.rebiun.org/rebiun/record/Rebiun21523162 m o d cr |n||||||||| 040915s2005 gw a ob 100 0 eng c 228376567 262680243 320977420 401413483 436368330 613458670 647650537 698452655 756420462 880013960 985062637 994808880 1005835969 1035712251 1044211220 1044261146 1056344464 1056396498 1060678022 1067029444 1077266992 1078347684 3540220925 hd. bd.) 9783540220923 hd. bd.) 9783540270553 electronic) 3540270558 electronic) 6610744076 9786610744077 10.1007/b138552 doi 978-3-540-22092-3 Springer http://www.springerlink.com COO eng pn COO WTU YDXCP UAB GW5XE CNTRU OCLCQ PUL AZU YNG E7B STF MNU IDEBK OCLCO OCLCQ A7U OCLCQ OCLCF BEDGE OCLCQ SLY OCL OCLCQ LVT VT2 OCLCO Z5A OCLCO OTZ OCLCQ OCLCO ESU OCLCQ OCLCO OCLCA OCLCQ MUO CEF U3W OCLCQ WYU OCLCO ICG OCLCO OCLCA UWO YOU CANPU pcc RM lcco MBGR bicssc PSD bicssc SCI049000 bisacsh MED067000 bisacsh Biocombinatorial approaches for drug finding W. Wohlleben, T. Spellig, B. Müller-Tiemann, editors Berlin New York Springer ©2005 Berlin New York Berlin New York Springer 1 online resource (xviii, 284 pages) illustrations (some color) 1 online resource (xviii, 284 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Ernst Schering Research Foundation workshop 0947-6075 51 Includes bibliographical references Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design -- Sources of Polyketides and Non-Ribosomal Peptides -- Polyketide Synthases: Mechanisms and Models -- Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases -- Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters -- Engineering Glycosylation in Bioactive Compounds by Combinatorial Biosynthesis -- Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds -- Enzymatic Incorporation of Halogen Atoms into Natural Compounds -- From Glucose to Antibiotics: What Controls the Fluxes? -- Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides -- Tool-Box: Tailoring Enzymes for Bio-Combinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery -- Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities Drug development- Congresses Bioactive compounds- Congresses Médicaments- Développement- Congrès Composés bioactifs- Congrès Bioactive compounds Drug Design Combinatorial Chemistry Techniques Peptide Biosynthesis Médicaments- Développement Composés bioactifs Drug development Biomédecine Sciences de la vie Bioactive compounds Drug development Drug Design Combinatorial Chemistry Techniques Peptide Biosynthesis Electronic books Conference papers and proceedings Wohlleben, W. Spellig, T. Müller-Tiemann, B. Springer e-books Springer e-books Print version Biocombinatorial approaches for drug finding. Berlin ; New York : Springer, ©2005 9783540220923 (OCoLC)57222109 Ernst Schering Research Foundation workshop 51. 0947-6075