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Gamma-glutamyl transpeptida...
Gamma-Glutamyl Transpeptidases (y-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the y-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released y-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). y-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.y-GT is upregulated during inflammation and in several human tumors, and it is involved in
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monografia Rebiun38453337 https://catalogo.rebiun.org/rebiun/record/Rebiun38453337 m o d cr cnu---unuuu 130722s2013 xx a ob 000 0 eng d 858656860 858763698 878018510 973348817 985063331 987922871 1005797988 1026464804 1066638182 1087353050 1097279433 1100979369 1110801309 1112566018 1119510864 1126410523 1162794592 1204016508 1227398532 1237484134 1241937053 1244637234 9783034806824 electronic bk.) 3034806825 electronic bk.) 3034806817 9783034806817 1299856853 ebk) 9781299856851 ebk) 9783034806817 10.1007/978-3-0348-0682-4 doi AU@ 000055903396 DEBSZ 431504571 NLGGC 363602429 NZ1 15736918 516936 MIL GW5XE eng pn GW5XE N$T YDXCP E7B GPM OCLCF COO IDEBK CDX EBLCP MEAUC NUI DEBSZ I9W VT2 UX0 OCLCQ UAB Z5A ESU OCLCQ IOG NJR BUF REB GILDS COS COF CEF U3W AU@ OCLCQ WYU TKN U3G CNTRU OCLCQ DCT ERF OCLCQ WURST SFB UKAHL OCLCQ SNK OCLCO CASUM OCLCO OCLCQ OCLCO OCLCQ OCLCL OCLCO (S SCI 007000 bisacsh PSBZ bicssc 572/.65 23 Castellano, Immacolata Gamma-glutamyl transpeptidases structure and function Immacolata Castellano, Antonello Merlino [Place of publication not identified] Springer 2013 [Place of publication not identified] [Place of publication not identified] Springer 1 online resource (52 pages) illustrations (some color) 1 online resource (52 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier PDF text file SpringerBriefs in biochemistry and molecular biology 2211-9353 Includes bibliographical references Preface; Contents; 1 Gamma-Glutamyl Transpeptidases: Structure and Function; Abstract; 1 ... Introduction; 2 ... Occurrence, Genes, and Gene Expression; 2.1 Hepatic Expression of gamma -GT; 2.2 gamma -GT Gene Structure; 2.3 Induction of Hepatic gamma -GT; 2.4 gamma -GT-Related Gene Products; 3 ... Structure and Function of gamma -GTs; 4 ... Autoprocessing and Reaction Mechanism of gamma -GTs; 4.1 Autoprocessing; 4.2 Reaction Mechanism; 4.3 gamma -Glutamyl Binding Site; 4.4 Acceptor Binding Site; 4.5 Transpeptidation Versus Hydrolysis; 4.6 Enzymatic Assays; 4.7 Biochemical Properties of gamma -GTs 4.8 Quest for Inhibitors4.9 Inhibitor Mechanisms; 4.10 Conformational Stability of gamma -GTs; 4.11 Search for Thermostable gamma -GTs; 5 ... gamma -GT in Bioclinical; 5.1 Pathways of gamma -GT Induction; 5.2 gamma -GT and Cancer; 5.3 gamma -GT and Cisplatin Resistance; 5.4 gamma -GT and Tumor Progression; 5.5 gamma -GT as a Target for Anticancer Treatments; 5.6 gamma -GT Complexes: Novel Biomarkers for Cancer and Other Pathologies; 6 ... gamma -GTs: Biotechnological and Biomedical Applications; 6.1 gamma -GTs in the Production of SCV-07 and of Glutamyl Phenyl Hydrazine Analogs 6.2 gamma -GTs as Cephalosporin Acylases6.3 gamma -GTs as Glutaminases; 6.4 gamma -GTs in the Production of Theanine; 6.5 gamma -GT to Release Drugs; 7 ... Conclusions; References Gamma-Glutamyl Transpeptidases (y-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the y-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released y-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). y-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.y-GT is upregulated during inflammation and in several human tumors, and it is involved in English Peptidase Transpeptidation Enzymes gamma-Glutamyltransferase- physiology Transglutaminases- physiology Peptide Hydrolases Enzymes Life Sciences Enzymology Human Physiology Biochemical Engineering Peptidases Transpeptidation Enzymes enzyme. SCIENCE- Life Sciences- Biochemistry. Peptidase. Transpeptidation. Life sciences Human physiology Biochemical engineering Enzymes Enzymology levenswetenschappen fysiologie physiology engineering biochemie biochemistry enzymologie Biology (General) Biologie (algemeen) Internet Resources Merlino, Antonello Springer eBooks Springer eBooks Print version Castellano, Immacolata. Gamma-glutamyl transpeptidases. [S.l.] : Springer Basel, 2013 3034806817 (OCoLC)843532438 SpringerBriefs in biochemistry and molecular biology