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Gamma-glutamyl transpeptida...
Gamma-Glutamyl Transpeptidases (y-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the y-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released y-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). y-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.y-GT is upregulated during inflammation and in several human tumors, and it is involved in
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monografia Rebiun25446136 https://catalogo.rebiun.org/rebiun/record/Rebiun25446136 m o d cr cnu---unuuu 130722s2013 xx a ob 000 0 eng d 858656860 858763698 878018510 973348817 985063331 987922871 1005797988 1026464804 1066638182 1087353050 1097279433 1110801309 1112566018 1119510864 9783034806824 electronic bk.) 3034806825 electronic bk.) 3034806817 9783034806817 1299856853 ebk) 9781299856851 ebk) 9783034806817 10.1007/978-3-0348-0682-4 doi AU@ 000055903396 DEBSZ 431504571 NLGGC 363602429 NZ1 15736918 516936 MIL GW5XE eng pn GW5XE N$T YDXCP E7B GPM OCLCF COO IDEBK CDX EBLCP MEAUC NUI DEBSZ I9W VT2 UX0 OCLCQ UAB Z5A ESU OCLCQ IOG NJR BUF REB GILDS COS COF CEF U3W AU@ OCLCQ WYU TKN U3G CNTRU OCLCQ DCT ERF OCLCQ WURST (S SCI 007000 bisacsh PSBZ bicssc 572/.65 23 Castellano, Immacolata Gamma-glutamyl transpeptidases structure and function Immacolata Castellano, Antonello Merlino [Place of publication not identified] Springer 2013 [Place of publication not identified] [Place of publication not identified] Springer 1 online resource (52 pages) illustrations (some color) 1 online resource (52 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda SpringerBriefs in biochemistry and molecular biology 2211-9353 Includes bibliographical references Preface; Contents; 1 Gamma-Glutamyl Transpeptidases: Structure and Function; Abstract; 1 ... Introduction; 2 ... Occurrence, Genes, and Gene Expression; 2.1 Hepatic Expression of gamma -GT; 2.2 gamma -GT Gene Structure; 2.3 Induction of Hepatic gamma -GT; 2.4 gamma -GT-Related Gene Products; 3 ... Structure and Function of gamma -GTs; 4 ... Autoprocessing and Reaction Mechanism of gamma -GTs; 4.1 Autoprocessing; 4.2 Reaction Mechanism; 4.3 gamma -Glutamyl Binding Site; 4.4 Acceptor Binding Site; 4.5 Transpeptidation Versus Hydrolysis; 4.6 Enzymatic Assays; 4.7 Biochemical Properties of gamma -GTs 4.8 Quest for Inhibitors4.9 Inhibitor Mechanisms; 4.10 Conformational Stability of gamma -GTs; 4.11 Search for Thermostable gamma -GTs; 5 ... gamma -GT in Bioclinical; 5.1 Pathways of gamma -GT Induction; 5.2 gamma -GT and Cancer; 5.3 gamma -GT and Cisplatin Resistance; 5.4 gamma -GT and Tumor Progression; 5.5 gamma -GT as a Target for Anticancer Treatments; 5.6 gamma -GT Complexes: Novel Biomarkers for Cancer and Other Pathologies; 6 ... gamma -GTs: Biotechnological and Biomedical Applications; 6.1 gamma -GTs in the Production of SCV-07 and of Glutamyl Phenyl Hydrazine Analogs 6.2 gamma -GTs as Cephalosporin Acylases6.3 gamma -GTs as Glutaminases; 6.4 gamma -GTs in the Production of Theanine; 6.5 gamma -GT to Release Drugs; 7 ... Conclusions; References Gamma-Glutamyl Transpeptidases (y-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the y-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released y-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). y-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.y-GT is upregulated during inflammation and in several human tumors, and it is involved in Peptidase Transpeptidation Life Sciences Enzymology Human Physiology Biochemical Engineering SCIENCE- Life Sciences- Biochemistry. Peptidase. Transpeptidation. Life sciences Human physiology Biochemical engineering Enzymes Enzymology levenswetenschappen fysiologie physiology engineering biochemie biochemistry enzymologie Biology (General) Biologie (algemeen) Electronic books Merlino, Antonello Print version Castellano, Immacolata. Gamma-glutamyl transpeptidases. [S.l.] : Springer Basel, 2013 3034806817 (OCoLC)843532438 SpringerBriefs in biochemistry and molecular biology