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Untranslated gene regions a...
"There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution"--Ebook's opening screen (EBL platform, viewed October 9, 2013)
Monografía
monografia Rebiun25928502 https://catalogo.rebiun.org/rebiun/record/Rebiun25928502 m o d cr cnu---unuuu 130710s2013 ne a ob 000 0 eng d 2013940950 858655957 862789252 985033006 1005798023 1066618798 1069645389 1097279130 1100932694 1110884825 1112530926 1119464715 1126437938 1136465070 1140059280 1148073826 9783034806794 electronic bk.) 3034806795 electronic bk.) 3034806787 9783034806787 1299856055 ebk) 9781299856059 ebk) 9783034806787 10.1007/978-3-0348-0679-4 doi 10.1007/978-3-0348-0 AU@ 000051763176 DEBSZ 397592426 NZ1 15028320 NZ1 15744809 516856 MIL GW5XE eng pn GW5XE YDXCP COO N$T OHS EBLCP MHW MEAUC GPM NHM E7B ZMC DEBSZ KMS OCLCQ OCLCO OCLCF IDEBK CDX OCLCQ VT2 MERER OCLCO Z5A OCLCO ESU OCLCQ OCLCO IOG OCLCO NJR OCLCO OCLCA BUF OCLCO GILDS CEF INT U3W AU@ OCLCQ WYU OCLCO YOU OCLCA TKN OCLCQ CNTRU OCLCQ U@J DCT ERF SFB UKAHL OCLCQ LQU SCI 049000 bisacsh QH lcco PSVH bicssc PSAK1 bicssc 572.8/8 23 Barrett, Lucy W. Untranslated gene regions and other non-coding elements regulation of eukaryotic gene expression Lucy W. Barrett, Sue Fletcher, Steve D. Wilton Basel New York Springer 2013 Basel New York Basel New York Springer 1 online resource (viii, 56 pages) illustrations (some color) 1 online resource (viii, 56 pages) Text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda SpringerBriefs in biochemistry and molecular biology 2211-9361 Includes bibliographical references (pages 43-56) Introduction -- Promoter -- 5' Untranslated region -- Intronic region -- 3' intronic region -- Non-coding RNAs -- Conclusion 1. Untranslated gene regions and other non-coding elements. 1. Introduction -- 2. Promoter. 2.1 Types of promoter; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters -- 3. 5' untranslated region. 3.1 Structure ; 3.2 Regulatory motifs -- 4. Intronic regions. 4.1 Organization and length; 4.2 Introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers -- 5. 3' Untranslated region. 5.1 MicroRNAs and the 3'UTR; 5.2 stabilisation and AU-rich elements; 5.3 Structure -- 6. Non-coding RNAs. 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs; 6.7 RNAs as extracellular signalling molecules; 6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs Preface; Contents; 1 Untranslated gene regions and other non-coding elements; Abstract; 1 ... Introduction; 2 ... Promoter; 2.1 Types of promoter; 2.1.1 Focused promoters; 2.1.2 Dispersed promoters; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters; 2.5 Conclusion; 3 ... 5vprime untranslated region; 3.1 Structure; 3.1.1 5vprime cap structure; 3.1.2 Secondary structure; 3.1.3 G-Quadruplexes; 3.1.4 Alternative 5vprimeUTRs; 3.2 Regulatory motifs; 3.2.1 IRES and cap-independent translation initiation; 3.2.2 uORFs; 3.3 Conclusion; 4 ... Intronic regions 4.1 Organization and length4.2 introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers; 5 ... 3vprime Untranslated region; 5.1 MicroRNAs and the 3vprimeUTR; 5.2 stabilisation and AU-rich elements; 5.3 structure; 5.3.1 Poly(A) Tail; 5.3.2 5vprime -- 3vprime interactions; 5.3.3 length; 5.3.4 secondary structure; 5.3.5 Alternative 3vprimeUTRs; 5.4 Conclusions; 6 ... Non-coding RNAs; 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs 6.7 RNAs as extracellular signalling molecules6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs; 7 ... Conclusion; References "There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution"--Ebook's opening screen (EBL platform, viewed October 9, 2013) English Non-coding RNA RNA, Untranslated SCIENCE- Life Sciences- Molecular Biology. Non-coding RNA. Life sciences Medical genetics Nucleic acids Plant breeding Animal Genetics and Genomics Plant Genetics & Genomics Gene Function Nucleic Acid Chemistry Electronic books Fletcher, Sue. Centre for Neuromuscular and Neurological Disorders (CNND), The University of Western Australia, Crawley, WA, Australia Wilton, Steve D. Print version Barrett, Lucy W. Untranslated gene regions and other non-coding elements. [S.l.] : Springer Basel, 2013 9783034806787 (DLC) 2013940950 (OCoLC)859583408 SpringerBriefs in biochemistry and molecular biology